RP 001 (hydrochloride) - CAS:1781880-34-9

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RP 001 (hydrochloride)

目录号 : KCM12036 CAS No. : 1781880-34-9 纯度 : ≥98%

Data Sheet 产品使用指南

RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P) agonist (EC = 9 pM). It is competitive with W146 , a selective S1P antagonist, and induces internalization and polyubiquitination of S1P in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC = 0.03 mg/kg). It reduces S1P-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1 mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock

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生物活性

RP 001 (hydrochloride) is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP 001 (hydrochloride) induces internalization and polyubiquitination of S1P1. RP 001 (hydrochloride) has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

体外研究

RP 001 (hydrochloride) elicits dose-dependent lymphopenia of CD4⁺ T cells. RP 001 (hydrochloride) induces acute lymphopenia with rapid recovery to untreated levels.

体内研究

RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC₅₀ of 0.03 mg/kg.

分子式

C₂₄H₂₄N₄O₄^.HCl

分子量

468.93

CAS号

1781880-34-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

DMSO: 29.4 mg/mL (62.70 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1325 mL	10.6626 mL	21.3251 mL
5 mM	0.4265 mL	2.1325 mL	4.265 mL
10 mM	0.2133 mL	1.0663 mL	2.1325 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%