MCTR1 (Synonyms:Maresin conjugates in tissue regeneration 1)
目录号 : KCM12041 CAS No. : 1784701-61-6 纯度 : ≥98%
Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ) in macrophages at the site of inflammation. DHA is oxidized to maresin 1 (MaR1;), which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate.
规格 价格 是否有货 数量
10 μg
In-stock
25μg
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50μg
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100μg
In-stock

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生物活性

MCTR1 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes tissue regeneration. Maresin conjugates in tissue regeneration 1 antagonize LTD4-stimulated vascular responses.

分子式
C32H47N3O9S
分子量
649.8
CAS号
1784701-61-6
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-80°C
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