Cortistatin-29 (rat) (trifluoroacetate salt) - CAS:1815618-17-7

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Cortistatin-29 (rat) (trifluoroacetate salt) (Synonyms:Cortistatin-29 (rat))

目录号 : KCM12101 CAS No. : 1815618-17-7 纯度 : ≥95%

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Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST, respectively. Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.

规格	价格	是否有货	数量
500μg		In-stock

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Other Forms of Rapamycin:

L-796,778 In-stock
Seglitide acetate In-stock
Cortistatin-29 (rat) (trifluoroacetate salt) In-stock
Octreotide In-stock
Octreotide acetate In-stock

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生物活性

Cortistatin-29 (rat) (trifluoroacetate salt) is a neuropeptide. Cortistatin-29 (rat) (trifluoroacetate salt) alleviates neuropathic pain. Cortistatin-29 (rat) (trifluoroacetate salt) binds all somatostatin (SS) receptor subtypes with high affinity and shows IC₅₀ values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 (rat) (trifluoroacetate salt) shows anti-fibrotic effects

体内研究

Cortistatin 29 (1-2 µg) can alleviate chronic neuropathic pain in mice.
Cortistatin 29 (1 nmol/mouse; Intraperitoneal injection; Three times a week, it showed anti fibrotic effects in mice.

Animal Model:	20-24 g body weight, 8-12 weeks-old mice
Dosage:	1 µg in 20 µL for s.c.; 2 µg in 200 µL for i.p.; 20 ng in 10 µL for i.t.
Administration:	Every other day for 12 days
Result:	Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.

分子式

C161H240N46O41S2.XCF3COOH

分子量

3540.04

CAS号

1815618-17-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥95%

Data Sheet

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Other Forms of Rapamycin:

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