AHU377-d4 - CAS:1884269-07-1

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AHU377-d4 (Synonyms:Sacubitril-d4;沙库必曲 d4)

目录号 : KCM12224 CAS No. : 1884269-07-1 纯度 : 98%

Data Sheet 产品使用指南

AHU377-d is intended for use as an internal standard for the quantification of AHU377 by GC- or LC-MS. AHU377 is a methyl ester prodrug form of the neprilysin inhibitor LBQ657 . It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.

规格	价格	是否有货	数量
500μg		In-stock
1mg		In-stock
5mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Thiorphan-d7 In-stock
LHW090-A7 In-stock
AHU377-d4 In-stock
Sacubitril/Valsartan In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

AHU377-d4(Sacubitril-d4) is a potent NEP inhibitor with an IC50 of 5 nMAHU377-d4(Sacubitril-d4) is a component of the heart failure medicine LCZ696.

分子式

C₂₄H₂₅D₄NO₅

分子量

415.52

CAS号

1884269-07-1

中文名称

(αR，γS)-γ-[(3-羧基-1-氧丙基-2,2,3,3-d4)氨基]-α-甲基-[1,1'-联苯]-4-戊酸α-乙酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO: 100 mg/mL (240.66 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4066 mL	12.0331 mL	24.0662 mL
5 mM	0.4813 mL	2.4066 mL	4.8132 mL
10 mM	0.2407 mL	1.2033 mL	2.4066 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%