19,20-Epoxycytochalasin C is a fungal metabolite originally isolated from Nemania sp. UM10M. It inhibits the growth of chloroquine-sensitive and -resistant strains of P. falciparum (ICs = 0.07 and 0.05 ng/ml, respectively) without inducing cytotoxicity in Vero cells (IC = >4,760 ng/ml). 19,20-Epoxycytochalasin C is also phytotoxic, reducing growth of lettuce and bentgrass plants when used at a concentration of 1 mg/ml.
19,20-Epoxycytochalasin C , a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity.
体外研究
19,20-Epoxycytochalasin C shows moderate toxicity to cell line SK-MEL with an IC50 of 8.02 µM.
体内研究
Evaluation of in vivo antimalarial activity of 19,20-Epoxycytochalasin C in a mouse model at 100 mg/kg dose shows that this compound has weak suppressive antiplasmodial activity and is toxic to animals.
分子式
C30H37NO7
分子量
523.62
CAS号
189351-79-9
中文名称
19,20-环氧细胞松弛素C
运输条件
Room temperature in continental US; may vary elsewhere.