CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC = 0.23 µM) with little activity at ABCG1. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 and to inhibit ATPase activity.
CAY10719 is a selective inhibitor for breast cancer resistance protein (ABCG2), with an IC50 of 0.238 µM. CAY10719 reverses the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity.
体外研究
CAY10719 exhibits cytotoxicity towards MDCK II BCRP and MDCK wild-type cells, with CI50s of 5.82 and 6.55 μM, respectively.
CAY10719 inhibits ATPase with an IC50 of 0.038 μM.
分子式
C25H20Cl2N2O2
分子量
451.34
CAS号
1942919-63-2
运输条件
Room temperature in continental US; may vary elsewhere.