Pramlintide (acetate hydrate) - CAS:196078-30-5

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Pramlintide (acetate hydrate) (Synonyms:醋酸普林兰肽)

目录号 : KCM12315 CAS No. : 196078-30-5 纯度 : ≥95%

Data Sheet SDS 产品使用指南

Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY), AMY, and AMY (ECs = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) (Aβ40;) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease.

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock

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Other Forms of Rapamycin:

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生物活性

Pramlintide (acetate hydrate) is a polypeptide analogue of human amylin. Pramlintide (acetate hydrate), an antidiabetic agent, is antineoplastic in colorectal cancer.

体外研究

Pramlintide (acetate hydrate) inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy for the latter (IC50 of 48.67 and 9.10 μg/mL, respectively).

Adding 5, 10, and 20 μg/mL Pramlintide (acetate hydrate) in combination with 5-fluorouracil, oxaliplatin, or irinotecan synergistically induces anti proliferative effects in HCT-116 and HT-29.

分子式

C₁₇₁H₂₆₇N₅₁O₅₃S₂^.XC₂H₄O₂[XH₂O]

分子量

3949.39 (free base)

CAS号

196078-30-5

中文名称

醋酸普兰林肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥95%

Data Sheet

SDS

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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