XAP044 - CAS:196928-50-4

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XAP044

目录号 : KCM12323 CAS No. : 196928-50-4 纯度 : ≥98%

Data Sheet 产品使用指南

XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC value of 88 nM. This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg	询价	In-stock

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Other Forms of Rapamycin:

Valiglurax In-stock
1-ethyl-3-morpholin-4-yl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile In-stock
DCPG In-stock
XAP044 In-stock
ACPT-II In-stock

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生物活性

XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.

分子式

C₁₅H₉IO₄

分子量

380.13

CAS号

196928-50-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

DMSO: ≥ 50 mg/mL (131.53 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6307 mL	13.1534 mL	26.3068 mL
5 mM	0.5261 mL	2.6307 mL	5.2614 mL
10 mM	0.2631 mL	1.3153 mL	2.6307 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%