1,2-Diphytanoyl-sn-glycero-3-PE - CAS:201036-16-0

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1,2-Diphytanoyl-sn-glycero-3-PE (Synonyms:DPyPE)

目录号 : KCM12373 CAS No. : 201036-16-0 纯度 : ≥95%

Data Sheet 产品使用指南

Phosphatidylethanolamines (PEs) are phospholipids found in biological membranes that serve both structural and functional roles. Different types of PE are commonly used in the generation of micelles, liposomes, and other types of artificial membranes. 1,2-Diphytanoyl-sn-glycero-3-PE is a phospholipid containing the tetramethylated long-chain (16:0) diphytanic acid inserted at the sn-1 and sn-2 positions.

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
250mg	询价	In-stock
500mg	询价	In-stock
10 mM * 1 mL in DMSO		In-stock

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生物活性

1,2-Diphytanoyl-sn-glycero-3-PE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. 1,2-Diphytanoyl-sn-glycero-3-PE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, 1,2-Diphytanoyl-sn-glycero-3-PE can be mixed with cationic lipids such as VC1052 (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin. 1,2-Diphytanoyl-sn-glycero-3-PE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane.

体外研究

1,2-Diphytanoyl-sn-glycero-3-PE, as a neutral auxiliary lipid, enhances the structural stability of liposomes, avoids excessive aggregation of cationic lipids, and may assist the complex in entering antigen-presenting cells. 1,2-Diphytanoyl-sn-glycero-3-PE does not directly participate in transfection, but indirectly enhances immune response by optimizing liposome properties, making Vaxfusin an adjuvant focused on activating humoral immunity.

分子式

C₄₅H₉₀NO₈P

分子量

804.17

CAS号

201036-16-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 200 mg/mL (248.70 mM; Need ultrasonic)

Ethanol : 10 mg/mL (12.44 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2435 mL	6.2176 mL	12.4352 mL
5 mM	0.2487 mL	1.2435 mL	2.4870 mL
10 mM	0.1244 mL	0.6218 mL	1.2435 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO → 40% PEG300 → 5% Tween-80 → 45% saline

Solubility: ≥ 2.5 mg/mL (3.11 mM); Clear solution

此⽅案可获得 ≥ 2.5 mg/mL (3.11 mM，饱和度未知) 的澄清溶液。

以 1 mL ⼯作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加⼊ 50 μL Tween-80，混合均匀；然后继续加⼊ 450 μL ⽣理盐⽔定容⾄ 1 mL。
2.

请依序添加每种溶剂： 10% DMSO → 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.11 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.11 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
3.

请依序添加每种溶剂： 10% DMSO → 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.11 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.11 mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL ⽟⽶油中，混合均匀
4.

请依序添加每种溶剂： 10% EtOH → 40% PEG300 → 5% Tween-80 → 45% saline

Solubility: ≥ 1 mg/mL (1.24 mM); Clear solution

此方案可获得 ≥ 1 mg/mL (1.24 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加⼊ 50 μL Tween-80，混合均匀；然后继续加⼊ 450 μL ⽣理盐⽔定容⾄ 1 mL。