| 生物活性 |
13(S)-HODE, the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. 13(S)-HODE is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. 13(S)-HODE induces mitochondrial dysfunction and airway epithelial injury[1][2]. |
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| 体外研究 |
13(S)-HODE (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium[2]. 13(S)-HODE (30 nM; 6 hours; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. 13(S)-HODE increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. 13(S)-HODE also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. |
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| 体内研究 |
13(S)-HODE (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury.
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| 分子式 |
C18H32O3
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| 分子量 |
296.44
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| CAS号 |
29623-28-7
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| 中文名称 |
13(s)-羟基-9z,11e-十八二烯酸
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： ≥98%
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