Guanylic acid (5'-GMP) - CAS:85-32-5

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Guanylic acid (5'-GMP) (Synonyms:鸟苷酸;鸟嘌呤核苷酸; 5'-GMP; 5'-guanosine monophosphate)

目录号 : KG10119 CAS No. : 85-32-5 纯度 : 98%

Data Sheet SDS 产品使用指南

Guanylic acid is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

规格	价格	是否有货	数量
100mg		In-stock	立即试用

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Other Forms of Rapamycin:

Deudextromethorphan (AVP-786) In-stock
(S)-ATPO In-stock
AMPA receptor antagonist-3 In-stock
Guanylic acid (5'-GMP) In-stock
JNJ-55511118 In-stock

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生物活性

Guanylic acid (5'-GMP) is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. Guanylic acid (5'-GMP) regulates the expression of genes related to fatty acid metabolism. Guanylic acid (5'-GMP) is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. Guanylic acid (5'-GMP) also causes neuronal cell death at high concentrations.

体外研究

Guanylic acid (5'-GMP) (50-500 μM, 48 h) It can regulate the expression of genes involved in fatty acid metabolism, affect the fatty acid composition in rainbow trout (Oncorhynchus mykiss) liver cells, and regulate fatty acid metabolism.

Cell Viability Assay

Cell Line:	Oncorhynchus mykiss hepatocytes
Concentration:	50-500 μM
Incubation Time:	12-48 hours
Result:	Upregulated the expressions of Δ5 fads2, elovl2, elovl5 and srebp-1. Downregulated the expression of pparα.

体内研究

Guanylic acid (5'-GMP) (10-150 mg/kg, ip, single dose) has shown anti anxiety effects in Wistar rat models.

Animal Model:	Wistar rats models
Dosage:	10-150 mg/kg
Administration:	ip, single dose
Result:	Increased the time rats spent in the light zone in the light-dark box test. Increased the time rats spent in the open arms in the elevated plus maze test.

分子式

C₁₀H₁₄N₅O₈P

分子量

363.22

CAS号

85-32-5

中文名称

鸟苷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H2O : 83.33 mg/mL (229.42 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7532 mL	13.7658 mL	27.5315 mL
5 mM	0.5506 mL	2.7532 mL	5.5063 mL
10 mM	0.2753 mL	1.3766 mL	2.7532 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%