Perflexane 是一种全氟碳化合物，既可作为全氟化碳（PFC）基微泡制剂的超声造影剂，也是高能聚焦超声（HIFU）疗法的增强剂。在HIFU应用中，Perflexane 能够提高治疗的效率和精确度，减少对周围正常组织的损伤。生物学功能方面，该化合物可增加 HO-1 和 IL-10 的表达，发挥抗氧化作用，从而减轻 LPS 诱导的肺损伤，因此可用于急性肺损伤的研究。然而，Perflexane 也具有发育毒性，可通过 NMDA 受体介导的 PKC-ERK/AMPK 信号通路诱导记忆障碍和神经蛋白下调，同时干扰小鼠的发情周期、排卵率、卵母细胞通讯及钙稳态。
| 生物活性 |
Perflexane is a perfluorocarbon compound that serves as both an ultrasound contrast agent for perfluorocarbon (PFC)-based microbubble formulations and an enhancer for high-intensity focused ultrasound (HIFU) therapy. In HIFU applications, Perflexane improves treatment efficiency and precision while minimizing damage to surrounding normal tissues. In terms of biological function, this compound increases the expression of HO-1 and IL-10, exerting antioxidant effects that mitigate LPS-induced lung injury, making it suitable for acute lung injury research. However, Perflexane also exhibits developmental toxicity, inducing memory impairment and downregulation of neurotrophic proteins via the NMDA receptor-mediated PKC-ERK/AMPK signaling pathway, while disrupting the estrous cycle, ovulation rate, oocyte communication, and calcium homeostasis in mice. |
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| 分子式 |
C6F14
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| 分子量 |
338.04
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| CAS号 |
355-42-0
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| 中文名称 |
全氟己烷
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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纯度： ≥95%
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