Alendronate sodium - CAS:129318-43-0

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Alendronate sodium (Synonyms:阿仑膦酸钠;Alendronic acid monosodium salt)

目录号 : KE9402 CAS No. : 129318-43-0 纯度 : ≥95%

Data Sheet SDS 产品使用指南

The compound binds and blocks farnesyl diphosphate synthase in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS). It causes macrophage apoptosis and inhibits prenylation and sterol biosynthesis in purified osteoclasts.

规格	价格	是否有货	数量
100mg		In-stock
10 mM * 1 mL in Water		In-stock

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生物活性

体内研究

Alendronate (1.5E^-10-1.5E^-7 M, administered by single intraventricular injection on the 7th day of embryonic development, exposed for 4 days) sodium can induce skeletal changes in a chicken embryonic development model.

Animal Model:	Viable fertilized chick eggs (7 days)
Dosage:	1.5E^-7 M, 1.5E^-8 M, 1.5E^-9 M, and 1.5E^-10 M
Administration:	intra-air cell injection, single dose at embryonic day 7, exposure for 4 days
Result:	Showed an 87.5% viability rate and a 75% viability rate at 1.5E^-10 M and other doses, respectively. Significantly reduced bone morphometric indexes (bone volume (BV) and bone surface (BS)) and cortical thickness in a dose-dependent manner. Significantly reduced dimensions and diminished mineralization in a concentration-dependent manner. Significantly increased TNFRSF11B, NF-κB1 and IL-6 levels, and decreased TNFRSF11A, CTSK, COL1A2, SPP1, and SOST levels, compared to control.

分子式

C₄H₁₂NNaO₇P₂

分子量

271.08

CAS号

129318-43-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H2O : 25 mg/mL (92.22 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6889 mL	18.4447 mL	36.8895 mL
5 mM	0.7378 mL	3.6889 mL	7.3779 mL
10 mM	0.3689 mL	1.8445 mL	3.6889 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%