Norharman-d7 - CAS:1216503-21-7

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Norharman-d7 (Synonyms:9H-吡啶[3,4-b]吲哚-d7;[2H7]-去甲哈尔满;[2H7]-9H-吡啶[3,4-B]吲哚)

目录号 : KM37010 CAS No. : 1216503-21-7

Data Sheet 产品使用指南

Norharman-d7 是氘代标记的 Norharmane。Norharmane (Norharman) 是一种 β-carboline 生物碱，是一种有效的可逆单胺氧化酶 (monoamine oxidase) 抑制剂，其对 MAO-A 和 MAO-B 的 IC50 分别为 6.5 and 4.7 μM。Norharmane 引起抗抑郁反应。Norharmane 还是一种很有前景的抗癌光敏剂。Norharmane 通过抑制 PIN2、PIN3 和 PIN7 转运蛋白来改变极性生长素转运，从而对拟南芥幼苗的生长产生显著的抑制作用。

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生物活性

Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.

分子式

C₁₁HD₇N₂

分子量

175.24

CAS号

1216503-21-7

中文名称

9H-吡啶[3,4-b]吲哚-d7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Data Sheet

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