Trontinemab
(Synonyms:RG6102)
目录号 : KM38519
CAS No. : 2568868-35-7
纯度 : 99%
Trontinemab (RG6102) 是一种脑渗透,抗淀粉样蛋白,双特异性和人源化的 IgG1-κ 抗体,靶向 Aβ 斑块和转铁蛋白受体1 (TFR1)。Trontinemab 结合原纤维 Aβ 和 Aβ 斑块,通过与阿尔茨海默病 (AD) 脑部分的免疫细胞结合,触发斑块清除。Trontinemab 对猕猴和人类的 TFR1 也表现出特定的亲和力。
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| 生物活性 |
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1.
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| 分子量 |
194.25 kDa
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| CAS号 |
2568868-35-7
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| 运输条件 |
Shipping with dry ice.
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| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
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