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17-phenyl trinor Prostaglandin F2α amide (Synonyms:N-Desethyl Bimatoprost)
目录号 : KCM11663 CAS No. : 155205-89-3 纯度 : ≥98%
Data Sheet 产品使用指南
17-phenyl trinor Prostaglandin F amide (17-phenyl trinor PGF amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters. 17-phenyl trinor PGF amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
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生物活性

17-phenyl trinor Prostaglandin F2α amide is a N-desethyl metabolite of Bimatoprost.
分子式
C23H33NO4
分子量
387.51
CAS号
155205-89-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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