Prostaglandins have a short life in vivo because NAD-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity. Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity. CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC value of 31 nM.
CAY10638 (15-PGDH-IN-2) is a 15-PGDH inhibitor with an IC50 value of 0.274 nM. CAY10638 (15-PGDH-IN-2) can be used in research on hair loss, bone formation, gastric ulcer healing, and dermal wound healing.
分子式
C16H13NO3S2
分子量
331.4
CAS号
1221413-57-5
运输条件
Room temperature in continental US; may vary elsewhere.