VU0360172 (hydrochloride) - CAS:1309976-62-2

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VU0360172 (hydrochloride) (Synonyms:VU0360172 盐酸盐)

目录号 : KCM10992 CAS No. : 1309976-62-2 纯度 : ≥98%

Data Sheet SDS 产品使用指南

VU036172 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5; K = 195 nM). It is selective for mGluR5 over mGluR1, mGluR3, and mGluR4 at 10 µM. VU036172 (20 and 50 µM) prevents TNF-α and nitric oxide (NO) production by IFN-γ- or LPS-stimulated BV-2 and primary microglial cells. It reduces the expression of inducible nitric oxide synthase (iNOS) and increases the expression of Ym1 and arginase 1 in LPS-stimulated BV-2 cells when used at a concentration of 20 µM. VU036172 (50 mg/kg) reduces the size of cortical lesions, prevents neuronal degeneration, and improves sensorimotor deficits in the beam walk test in a mouse model of traumatic brain injury (TBI), indicating improved recovery of motor function.

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock

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生物活性	VU0360172 (hydrochloride) is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 (hydrochloride) stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice.
分子式	C₁₈H₁₅FN₂O^.HCl
分子量	330.78
CAS号	1309976-62-2
中文名称	VU0360172 盐酸盐
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)