Pirinixic Acid Aminothiazole - CAS:1492060-44-2

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Pirinixic Acid Aminothiazole (Synonyms:5-LO/mPGES1-IN-1)

目录号 : KCM11550 CAS No. : 1492060-44-2 纯度 : ≥98%

Data Sheet 产品使用指南

Microsomal prostaglandin E synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE and leukotrienes (LTs), respectively. PGE and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer. Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (ICs = 0.4 and 0.2 µM, respectively). It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms. Pirinixic acid aminothiazole reduces the synthesis of PGE and LTC during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock

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生物活性

Pirinixic Acid Aminothiazole is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC50 values are 0.3 and 0.4 μM, respectively. Pirinixic Acid Aminothiazole has anti-inflammatory activity.

体内研究

Pirinixic Acid Aminothiazole (10 mg/kg, intraperitoneal injection, pre-treatment 30 minutes before peritonitis induction) can reduce vascular permeability and inflammatory cell infiltration in a zymosan induced mouse peritonitis model, accompanied by impaired levels of cysteine leukotrienes and prostaglandin E2.

Animal Model:	Zymosan-Induced Peritonitis in Mice
Dosage:	10 mg/kg
Administration:	i.p. pretreated 30 minutes before peritonitis induction
Result:	Reduced vascular permeability by 57% and inhibited neutrophil infiltration by 45%.

分子式

C₂₅H₂₅ClN₄O₂S₂

分子量

513.1

CAS号

1492060-44-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

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