U-51605 - CAS:64192-56-9

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U-51605

目录号 : KCM14675 CAS No. : 64192-56-9 纯度 : ≥98%

Data Sheet 产品使用指南

U-51605 is a stable analog of the endoperoxide prostaglandin H (PGH). It is an inhibitor of both prostacyclin (PGI) and thromboxane (TX) synthases with more selectivity towards PGI synthase. U-51605 is also a partial agonist at TP receptors. In human foreskin fibroblasts, U-51605 inhibits PGI synthase at a concentration of 2.8 µM, whereas, human platelet TX synthase is inhibited at a concentration of 5.6 µM. At concentrations up to 1 µM, U-51605 reduced the release of prostacyclin in SHR aorta elicited by the calcium ionophore A-23187 with no effect on TXA production and yet significantly increased PGE and PGF release.

规格	价格	是否有货	数量
100μg		In-stock
500μg		In-stock
1mg		In-stock
5mg		In-stock

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生物活性	U-51605 is a platelet aggregation inhibitor and inhibits thromboxane synthesis. U-51605 is also a prostaglandin I2 synthase inhibitor and can inhibit the retinal vasodilation response induced by NO donors (such as NOR3).
体外研究	U-51605 (3 μM) inhibits acetylcholine induced endothelial dependent contraction. U-51605 (0.5, 1, 3, 10 μM) increased acetylcholine induced release of PGE2 and PGF2 α .
分子式	C₂₀H₃₂N₂O₂
分子量	332.48
CAS号	64192-56-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-80°C