FTase Inhibitor II - CAS:156707-43-6

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FTase Inhibitor II (Synonyms:FTase-IN-2 ；N-[4-[[(2R)-2-氨基-3-巯基-1-氧代丙基]氨基]苯甲酰基]-L-蛋氨酸)

目录号 : KCM11697 CAS No. : 156707-43-6 纯度 : ≥80%

Data Sheet 产品使用指南

Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function at, membranes. FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC = 50-75 nM), preventing farnesylation of Ras. It does not inhibit geranylgeranyl transferase at similar concentrations (IC > 100 µM). FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock

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Other Forms of Rapamycin:

FTase Inhibitor II In-stock
FTase Inhibitor I In-stock
α-hydroxy Farnesyl Phosphonic Acid In-stock

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生物活性

FTase Inhibitor II is a farnesyltransferase inhibitor, with IC₅₀ values of 150 nM and 1500 nM against FTase and GGTase I, respectively. FTase Inhibitor II is not farnesylated by FTase, thus avoiding metabolic inactivation.

分子式

C₁₅H₂₁N₃O₄S₂

分子量

371.47

CAS号

156707-43-6

中文名称

N-[4-[[(2R)-2-氨基-3-巯基-1-氧代丙基]氨基]苯甲酰基]-L-蛋氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥80%

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation