ARN726
(Synonyms:N-[(3S)-2-氧代-3-氮杂环丁烷基]-氨基甲酸-4-环己基丁酯)
目录号 : KCM11828
CAS No. : 1628343-77-0
纯度 : ≥95%
ARN726 is an inhibitor of N-acylethanolamine acid amidase (NAAA; ICs = 27 and 63 nM for the human and rat enzyme, respectively). It is selective for NAAA over fatty acid amide hydrolase (FAAH) and acid ceramidase (ICs = >100 and 12.5 μM, respectively), as well as a panel of 28 lipid metabolism- and inflammation-related enzymes at 10 μM. ARN726 (1-30 mg/kg) decreases lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation. It inhibits NAAA and reverses complete Freund's adjuvant-induced decreases in palmitoyl ethanolamide (PEA; ) and oleoyl ethanolamide (OEA; ) levels in inflamed paw tissue in a rat model of arthritis.
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| 分子式 |
C14H24N2O3
|
| 分子量 |
268.35204
|
| CAS号 |
1628343-77-0
|
| 中文名称 |
ARN726
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|