ML-356
目录号 : KCM12090 CAS No. : 1808260-45-8 纯度 : ≥98%
ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE; IC = 334 nM). It is selective for FASN over a number of other human thioesterases expressed in tumor cells, and selective for FASN-TE over its most closely related human homolog, ACOT4. In cells, ML-356 has been shown to block the biosynthesis of palmitate, the end product of FASN.
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生物活性

ML-356 is an inhibitor for fatty acid synthase (FAS), that inhibits the thioesterase domain of FAS (FAS TE) with an IC50 of 0.334 μM, and blocks the de novo palmitate synthesis in PC-3 cell with an IC50 of 20 μM. ML356 exhibits good membrane permeability, and good stability in human and mouse plasma.

分子式
C19H25N3O4S2
分子量
423.55
CAS号
1808260-45-8
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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