BMS 195614 - CAS:182135-66-6

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BMS 195614 (Synonyms:BMS 195614/BMS 614)

目录号 : KCM12108 CAS No. : 182135-66-6 纯度 : ≥98%

Data Sheet 产品使用指南

BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (K = 2.5 nM). It antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock
10 mM * 1 mL in DMSO		In-stock

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Other Forms of Rapamycin:

HX 531 In-stock
BMS 189961 In-stock
BMS 195614 In-stock
all-trans-5,6-epoxy Retinoic Acid In-stock
Oxybenzone In-stock

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生物活性

BMS 195614 is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS 195614 restores the expression of Bcl2.BMS 195614 inhibits the transactivation of NF-κB, AP-1 and PPAR.BMS 195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis.

体外研究

BMS 195614 (10-20 μM) can reduce blue light induced phototoxicity and regulate inflammation and angiogenesis in the presence of A2E in RPE cells.
BMS 195614 (6 μM, 24 h) can reverse the anti-inflammatory effects of Vitamin A and RA on LPS activated BV-2 cells releasing IL-6.
BMS 195614 (1 μM, 24 h) can inhibit the migration of MC3T3E1 osteoblast like cells induced by Retinoic acid.

Real Time qPCR

Cell Line:

RPE cells

Concentration:

10 µM

Incubation Time:

Result:

Inhibited NF-κB transactivation, the transactivation of AP-1, the expression of IL-6 and VEGF mRNA.

体内研究

BMS 195614 (2-10 mg/kg, orally, 7 days) showed no or only slight inhibition on overall spermatogenesis in mice.

分子式

C₂₉H₂₄N₂O₃

分子量

448.51

CAS号

182135-66-6

中文名称

BMS 195614/BMS 614

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO: 30 mg/mL (66.89 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2296 mL	11.1480 mL	22.2960 mL
5 mM	0.4459 mL	2.2296 mL	4.4592 mL
10 mM	0.2230 mL	1.1148 mL	2.2296 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

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浓度

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Other Forms of Rapamycin:

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