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BMS 189961 (Synonyms:BMS961)
目录号 : KCM12184 CAS No. : 185629-22-5 纯度 : ≥98%
Data Sheet 产品使用指南
BMS 189961 is an agonist of retinoic acid receptor γ (RARγ; EC = 30 nM in a transactivation assay). It is selective for RARγ over RARβ (EC = 1,000 nM). In vitro, BMS 189961 decreases long bone growth and digit formation of isolated mouse embryonic limb buds when used at concentrations of 0.01 and 0.1 µM. Topical administration of BMS 189661 (40 nmol) increases the skin expression of retinoid metabolism-related genes, including Rdh10, Crabp2, and Krt4, as well as epidermal barrier genes, including Spink5, Klk5, and Klk7, in mice.
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生物活性

BMS 189961 is a selective retinoic acid receptor-γ (RARγ) agonist. BMS 189961 shows anti-inflammatory activity.
体外研究

BMS 189961 inhibits the expression of Dectin-1 and pro-inflammatory cytokines.
分子式
C23H26FNO4
分子量
399.46
CAS号
185629-22-5
中文名称
3-氟-4-[[2-羟基-2-(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)乙酰基]氨基]苯甲酸
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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