Leteprinim is a nootropic and neuroprotective agent and a derivative of hypoxanthine . Leteprinim (10 and 100 µM) enhances nerve growth factor induced neurite growth in PC12 cells and increases the production of synaptophysin when used at concentrations ranging from 5 to 100 ng/ml. It enhances working memory in a win-shift T-maze test in young mice and reduces time delay-induced working memory errors in old mice with mild or moderate, but not severe, age-induced memory deficits when administered at a dose of 30 mg/kg. In a rat model of spinal crush injury, leteprinim (60 mg/kg per day for 21 days) reduces impairments in locomotor function and reduces increases in the amount of necrotic tissue and the number of reactive astrocytes in the spinal cord. It reduces hypoxia-induced decreases in neuronal density in the hippocampal CA1, CA3, and dentate gyrus regions and decreases the number of caspase-3 and TUNEL-positive cells in the hippocampus and prefrontal and parietal cortices in neonatal rats when administered at a dose of 60 mg/kg.
| 生物活性 |
Leteprinim (potassium salt) , a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim (potassium salt) is a hypoxanthine derivative neurotrophic agent. Leteprinim (potassium salt) can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim (potassium salt) reduces glutamate toxicity in cultured hippocampal neurons.Leteprinim (potassium salt) increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species. |
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| 体外研究 |
Leteprinim (5-50 ng/mL, 24 and 48 hours) potassium can enhance neurotransmitter release and increase the secretion of synaptophysin in PC12 cells. |
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| 体内研究 |
Leteprinim (30 or 60 mg/kg, intraperitoneal injection for 7 days) and potassium can protect rats from hippocampal neuronal excitotoxicity induced by kainic acid (12 mg/kg).
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| 分子式 |
C15H12N5O4.K
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| 分子量 |
365.39
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| CAS号 |
192564-13-9
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| 中文名称 |
4-[3-(6-氧代-3H-嘌呤-9-基)丙基氨基]苯甲酸钾
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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纯度： ≥98%
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