Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADDs) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing.Perlapine displays >10,000-fold selectivity for hM3Dq over hM3.
Perlapine is a potent muscarinic DREADD (Designer Receptors Exclusively Activated by Designer agents) agonist Perlapine exhibits >10000-fold selectivity for hM3Dq over hM3 receptors.
分子式
C19H21N3
分子量
291.39
CAS号
1977-11-3
中文名称
甲哌氮草
运输条件
Room temperature in continental US; may vary elsewhere.