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ARN14974
目录号 : KCM11861 CAS No. : 1644158-57-5 纯度 : ≥95%
Data Sheet 产品使用指南
ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase (IC = 79 nM). It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice.
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1mg
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5mg
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10mg
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25mg
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分子式
C24H21FN2O3
分子量
404.4
CAS号
1644158-57-5
中文名称
AcidCeramidaseInhibitor17a
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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