(±)17-HETE - CAS:128914-47-6

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(±)17-HETE

目录号 : KCM10936 CAS No. : 128914-47-6 纯度 : ≥98%

Data Sheet 产品使用指南

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 µM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.

规格	价格	是否有货	数量
25μg		In-stock
50μg		In-stock
100μg		In-stock

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Other Forms of Rapamycin:

Ouabain In-stock
(±)17-HETE In-stock
(±)16-HETE In-stock
Digoxin-d3 In-stock
Bufalin In-stock

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生物活性

17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2].

体外研究

17-HETE (5-20 μM) promotes the development of human cardiac hypertrophy by enhancing the activity and protein levels of CY1B1.

Real Time qPCR

Cell Line:	AC16
Concentration:	5-20 µM
Incubation Time:	24 hours
Result:	Increased mRNA levels of β-MHC and ANP, increased cell surface area.

Western Blot Analysis

Cell Line:	AC16
Concentration:	20 µM
Incubation Time:	24 hours
Result:	Increased expression of CYP 1B1.

体内研究

17-HETE (1-20 μg, arterial injection) stereospecifically (S-enantiomer) inhibits proximal tubular ATPase activity in New Zealand white rabbits [2].

Animal Model:	New Zealand White rabbit
Dosage:	1-20 μg
Administration:	injection into artery
Result:	17S inhibited more than 70% ATPase activity at the concentration of 2 μM, while 17R enantiomer remained inactive.

分子式

C₂₀H₃₂O₃

分子量

320.5

CAS号

128914-47-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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