17(S)-HETE - CAS:183509-25-3

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17(S)-HETE

目录号 : KCM12145 CAS No. : 183509-25-3 纯度 : ≥98%

Data Sheet 产品使用指南

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 µM.

规格	价格	是否有货	数量
25μg		In-stock
50μg		In-stock
100μg		In-stock

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Other Forms of Rapamycin:

Sodium chloride, for cell culture In-stock
Ouabain In-stock
17(S)-HETE In-stock
(±)17-HETE In-stock
(±)16-HETE In-stock

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生物活性

17(S)-HETE is arachidonic acid metabolite through cytochrome P-450 pathways. 17(S)-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.

体外研究

17(S)-HETE (5-20 μM) promotes the development of human cardiac hypertrophy by enhancing the activity and protein levels of CY1B1.

Real Time qPCR

Cell Line:	AC16
Concentration:	5-20 µM
Incubation Time:	24 hours
Result:	Increased β/α-MHC ratio, mRNA levels of β-MHC, ANP and CYP1B1, cell surface area by 124%, 250%, 120%, 210% and 117%, respectively.

Western Blot Analysis

Cell Line:	AC16
Concentration:	20 µM
Incubation Time:	24 hours
Result:	Increased levels of CYP1B1.

体内研究

17(S)-HETE (1-20 μg, arterial injection) inhibits proximal tubular ATPase activity in New Zealand white rabbits.

Animal Model:

New Zealand White rabbit

Dosage:

1-20 μg

Administration:

injection into artery

Result:

Inhibited more than 70% ATPase activity at the concentration of 2 μM.

分子式

C₂₀H₃₂O₃

分子量

320.47

CAS号

183509-25-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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